Altered expression of some molecular chaperones, the major component of protein folding and quality control in the ER, was found in proteomics of a murine model of retinal degeneration.11,167–169 Some mutations in rhodopsin, which result in the production of misfolded proteins, lead to retinitis pigmentosa (RP). The gene discussed is RHO; the disease is retinitis pigmentosa 1.