Intravitreal plasmin injection before or during vitrectomy has been studied in multiple case series for diabetic macular edema associated with a thick and adherent posterior hyaloid face,25 idiopathic and traumatic macular holes,26–28 proliferative diabetic retinopathy,29 diabetic tractional retinal detachment,30 vitreomacular traction syndrome31 and retinopathy of prematurity.32,33. This evidence concerns the gene PLG and retinopathy of prematurity.