PLG and macular holes: Although there is no randomized clinical trial comparing macular hole closure rates and complications of vitrectomy with and without plasmin, multiple small case series suggest that plasmin facilitates vitreous surgery.26–28,37 In a retrospective study, Wu et al27 reported the results of autologous plasmin enzyme assisted vitrectomy on 13 pediatric patients aged 1–15 years with a traumatic macular hole.