Mutation of Foxp3 gene results in fatal autoimmune disorders in human, for example, immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome or in mice, for example, lymphoproliferative disorder and stable expression of Foxp3 is essential for immune homeostasis [155, 156]. This evidence concerns the gene FOXP3 and polyendocrinopathy.