ATM and ataxia telangiectasia: In particular, it has been reported that genes involved in signaling pathway which coordinates cell cycle arrest after DNA DSB, such as the ataxia telangiectasia mutated gene (ATM), are associated, when defective, with neurodegenerative disorders (ataxia-telangiectasia and ataxia-telangiectasia-linked disorder, AT and ATLD) [15].