Concordantly hypermethylated CpGs were associated with genes involved in Cadherin, Wnt and Notch signaling pathways, many of which have been previously reported as frequently methylated in a variety of neoplasms, such as APC2 [27], [28], SFRP2 [29], CDH13 [30], [31], CDH15 [32] and PCDH10 [33], [34] (see Table S4). Here, APC2 is linked to neoplasm.