Both in normal CD34+ samples and leukemia specimens, hypomethylation within CpG islands overlapping TSSs was associated with highly expressed genes, while hypermethylation was observed for low expression genes (top and bottom 15th percentile of expressed transcripts, Wilcoxon rank sum test p-value<0.005) (Figure 6 and Figure S6). Here, CD34 is linked to leukemia.