However, in contrast to the ELISPOT assay showing frequencies of IFN-γ+CD8+Tcells specific to apoptotic peptides significantly higher in patients experiencing chronic infection than in patients with self-limited infection (Fig. 1A), the total frequencies of either apoptotic or viral epitope-specific CD8+ T cells, as detected by pentamers, did not differ between patients undergoing chronic or recovery evolution at all the time points tested (Fig. 1D–F). The gene discussed is IFNG; the disease is infection.