Concentrations of 100–400 μΜ, at which palmitate significantly induces IL-6 and MCP-1 secretion in orbital fibroblasts, would be pathologically relevant in patients with hyperthyroidism, as the proportion of palmitate in FFAs is about 25% [30] and plasma FFAs levels increase to 800–1,000 μΜ in patients with hyperthyroidism [6]. This evidence concerns the gene IL6 and hyperthyroidism.