NOS2 and Hyperglycemia: Most of the aggravating effects of diabetes on hypertensive retinas were corrected by reestablishing the redox balanced state and inducible nitric oxide synthase suppression using an exogenous superoxide dismutase mimetic [33] or angiotensin receptor blocker [37,38], indicating the convergence between hyperglycemia and the rennin-angiotensin system on oxidative stress pathways that may also lead to associated increases in inflammation.