A significant negative correlation was found between NM modulation of Matrigel invasion inhibition and MMP-9 secretion with breast cancer MDA-MB-231 (r= − 0.851) and MCF-7 (r= −0.993) cell lines and with uterine cancer SK-UT-1 cell line (r= −0.910). The gene discussed is MMP9; the disease is uterine cancer.