FOXP1 and neurodevelopmental disorder: The first hint that FOXP1 may be involved in neurodevelopmental disorders was provided by a heterozygous deletion in 3p14.1, which affected FOXP1, EIF4E3, PROK2 and GPR27, in a patient with speech delay, hypertonia and additional phenotypes (for details see Table 2) (Pariani et al. 2009).