The tumor cells were strongly positive for melanoma marker (HMB45), Melan-A, S-100 protein (Figure 3A-C) and vimentin, whereas CD20, CD45RO, CD3, CD79α, myeloperoxidase, terminal deoxynucleotidyl transferase, pan cytokeratin (AE1/AE3), keratin 5/6, keratin 7, synaptophysin, chromogranin A, and sarcoma markers such as smooth muscle actin, desmin, CD117, CD34 were all negative. The gene discussed is PMEL; the disease is melanoma.