Specifically, we may believe that occlusal balance symmetrization can determine, in the trigeminal/LC-NE mesencephalic nucleus pathway, a coerulean activation on the hypoactive occlusal side and a concomitant contralateral reduction which, moreover, could also determine a lower galanin release, normally hyperexpressed in AD, from noradrenergic terminations [23,24]. This evidence concerns the gene GAL and Alzheimer disease.