By contrast, only 4.4% (± 0.7) and 8.1% (± 2.1) of pDCs from SLE subjects produced IFN-α (P < 0.0001), as compared to healthy controls) and TNF-α (P < 0.0001, as compared to healthy controls) (Figure 2A). This evidence concerns the gene IFNA1 and systemic lupus erythematosus.