Children with eczema by 24 months on average had higher total IgE levels at 60 months of age than children without eczema, regardless of whether they were defined as nonsensitized (GM = 39 IU/mL, n = 67 vs. 24 IU/mL, n = 152; p = 0.016) or sensitized to indoor aeroallergens (GM = 207 IU/mL, n = 22 vs. 107 IU/mL, n = 50; p = 0.056). The gene discussed is IGHE; the disease is Eczematoid dermatitis.