Abraham E, Wunderink R, Silverman H, Perl TM, Nasraway S, Levy H, Bone R, Wenzel RP, Balk R, Allred R: Efficacy and safety of monoclonal-antibody to human tumor-necrosis-factor-alpha in patients with sepsis syndrome - a randomized, controlled, double-blind, multicenter clinical-trial. JAMA-Journal of the American Medical Association 1995, 273:934-941. The gene discussed is TNF; the disease is systemic inflammatory response syndrome.