Moreover, we found that all the 14 claspin immunoreactive cases were also HC2 positive and 13 out of these had a histologically confirmed lesion (4 L-SIL: 2 CIN1 and 2 CIN2; 9 H-SIL: 6 CIN2 and 3 CIN3; data not shown). This evidence concerns the gene CLSPN and squamous cell intraepithelial neoplasia.