UBB and Alzheimer disease: In the brainstem of sporadic AD patients (Braak stage #6 and less prominent in stages #3 and #5) comparable nuclei as in the UBB+1 tg mouse line 3413 mouse were stained positively for misfolded Tau and UBB+1 in the pneumotaxic centers of the brain (Fig. 4a–g), e.g., in the locus coeruleus, subcoeruleus, the lateral and medial parabrachial nuclei, the subpeduncular pigmented nucleus and the sagulum.