MMP2 is also implicated in non-physiological tissue invasion, allowing tumor cell invasion and metastasis in breast (Jezierska and Motyl 2009), lymph (Tokuraku et al. 1995), ovarian (Kenny et al. 2008) and colorectal (Murnane et al. 2009) cancers, as well as in others. This evidence concerns the gene MMP2 and neoplasm.