When episodes of severe hypoglycaemia and nocturnal hypoglycaemia were separately analysed, insulin detemir, but not insulin glargine, was associated with a reduced risk compared to human NPH insulin (OR 0.73 (0.60 - 0.89), p = 0.002 and OR 0.69 (0.55 - 0.86), p = 0.001; respectively). This evidence concerns the gene INS and Hypoglycemia.