INS and type 1 diabetes mellitus: After the initiation of the present study, a meta-analysis based on 20 studies (duration > 12 weeks) was published comparing long-acting insulin analogues with long-acting human insulin in type 1 diabetes, including 12, 15 and 13 studies analysing any hypoglycaemia, severe hypoglycaemia, and nocturnal hypoglycaemia, respectively [17].