The best cut-off of CK, ALT and AST for identifying patients with high risk of developing Myo-SSc within three years after inclusion were 92 U/L (24.1 to 259.4), 18.0 U/L (9.7 to 32.7), and 25.0 U/L (13.2 to 39.2), respectively. Here, GPT is linked to systemic sclerosis.