In 2004, Hans et al found that according to the expression of CD10, BCL-6 and MUM-1, diffuse large B-cell lymphoma (DLBCL) could be categorized into two subtypes: germinal centre B cell-like (GCB) and non-germinal centre B cell-like (non-GCB) phenotypes. This evidence concerns the gene IRF4 and diffuse large B-cell lymphoma.