Different levels of several antioxidant proteins (selenium binding protein, superoxide dismutase, thioredoxin-dependent peroxide reductase, peroxiredoxin-4 and peroxiredoxin-6) suggest an increased level of oxidative stress in UC patients, and earlier studies have specifically documented a regulation of selenium-binding protein and superperoxide dismutase in relation to patients with IBD [26,44-46]. The gene discussed is PRDX4; the disease is inflammatory bowel disease.