Feiguin et al. reported that Drosophila lacking TBPH presented deficient locomotive behaviors, reduced life span and anatomical defects at neuromuscular junctions (NMJ), suggesting that a loss of TDP-43 nuclear functions could be a causative factor of the neurodegeneration observed in patients with ALS/FTLD [37]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.