To investigate whether a Rab cluster (consisting of a given Rab protein and its interacting partners, see Figure 4 and Figure S1) could be specifically associated with bladder cancer progression, we used the statistical binomial test to determine whether the percentage of genes deregulated within a given Rab cluster was significantly greater than the percentage obtained by analyzing all the Rab and Rab-interacting protein genes. Here, AGFG1 is linked to urinary bladder carcinoma.