LEPRE1, MICAL2, RAB23 and STXBP1 were specifically up-regulated in the muscle-invasive FGFR3-non-mutated tumors as compared to both normal urothelium and muscle-invasive FGFR3-mutated tumors, suggesting that these genes play an active role in tumor progression along the FGFR3-non-mutated tumor pathway. This evidence concerns the gene FGFR3 and neoplasm.