Among the genes found to be deregulated during bladder cancer progression (Table 2 and Table 3), 13 were common to both pathways, 10 down-regulated: EEA1, ICA1, MLPH, MYO5B, MYO5C, PIGR, RAB14, RPH3AL, SYTL2, TBC1D30 and 3 up-regulated: CAV1, ITGA5, MICAL1. In order to search for genes specifically deregulated in each pathway, we proceeded in two steps. The gene discussed is PIGR; the disease is urinary bladder cancer.