PECAM1 and atherosclerosis: In addition, single nucleotide polymorphisms of CD31 encoding amino acid substitutions at positions affecting the binding site [6] and the intracellular ITIMs [7] are associated with increased severity of graft-versus-host disease after hematopoietic stem cell transplantation [8], [9], [10], [11], [12] and atherosclerosis [7], [13].