The analysis of these 42 genes showed that LHFPL3, SLC26A4, SLC26A3, NRCAM, DOCK4, DLD, RELN are associated with some congenital diseases or cancers, and COG5, CBLL1, DNAJB9, IMMP2L, PNPLA8, GPR22, PIK3CG, PRKAR2B, NAMPT, RINT1, MLL5 express proteins that may be involved in cellular and structural functions might be good candidates for HIBM4. The gene discussed is GPR22; the disease is cancer.