As for the subgroup analysis for the presence of nasal polyps (CRSwNP and CRSsNP) displayed significant association in CRSwNP cohorts regarding to one SNP in RYBP (rs4532099) and 5 SNPs IRAK4 (rs4252431, 6582484, rs1461567, rs4251559 and rs3794262) (Table 6). The gene discussed is RYBP; the disease is Nasal polyposis.