In contrast to AOAH gene, polymorphisms in the RYBP gene was exhibited here for the first time as a significantly risk factor of CRS and either of the subgroups (CRSsNP and CRSwNP) with high OR values (ORCRS = 2.59; ORCRSsNP = 2.76; ORCRSwNP = 2.45), suggesting the variation of rs4532099 in RYBP could increase the risk of CRS development. This evidence concerns the gene AOAH and congenital rubella syndrome.