STAT3 and cancer: As shown in Figure 4D, miR-337-3p mimic sensitizes cells to cucurbitacin, decreasing the IC50 from 1.14 μM (95% CI 1.03–1.28) to 0.37 μM (95% CI 0.33–0.42) (p <0.0001), indicating that targeting both STAT3 expression with miR-337-3p mimic and STAT3 activation with cucurbitacin has a synergistic effect on cancer cell survival, and suggesting that miR-337-3p may also serve as an adjuvant to STAT3 inhibitors.