Considering the potential of endosomal TLR signals to induce proinflammatory cytokine expression, UNC93B1 deficient 3d mice were first assessed for systemic IFN-α, IFN-γ, IL-12 and TNF-α production during early infection with a moderate (5×104 PFU) dose of MCMV. The gene discussed is TNF; the disease is infection.