In addition, Cox proportional hazards regression was performed for peak versus base subjects with adjustments for respective Cox univariate significant clinical covariates and biomarkers for HR1 (age, BMI, hypertension, metabolic syndrome, HDL-C, cholesterol, triglycerides, and apoE) and HR2 (age, BMI, hypertension, cholesterol, LDL-C, triglycerides, apoB and apoE). This evidence concerns the gene APOE and Hypertension.