[14] The mutational site of p53 in gastric cancer is wide and the reported incidence of p53 mutations ranges from 3.2 to 65% [15] and we observed in 4.6% of cases using a subset of known p53 mutation sites. The incidence of p53 mutation was significantly lower in EBV-GC (n = 1) when compared with non-EBV-GCs (n = 10), which is in line with previous reports that EBV infection might substitute mutations of p53 during the gastric tumorigenesis. [16]. This evidence concerns the gene TP53 and Epstein-Barr virus infection.