[11], [12] Few studies have reported on the frequency of PIK3CA mutations in the range of 4 to 25% of gastric cancers. [13] A relatively wide range of PIK3 mutation in previous reports (4 to 25%) may owe to the fact that PIK3CA mutation was studied in small cohort of archival tissue specimens (n = 12 to 94) or different stages of cancer analyzed among various studies. Extensive clinicopathologic correlative analyses or functional studies have not been actively investigated in this tumor type, [12] rendering limited implications of PIK3CA mutations in gastric cancer. This evidence concerns the gene PIK3CA and gastric cancer.