EGFR and cancer: A further analysis of the effects of YM155 on EGFR expression in various cancer cell lines showed that YM155 induced a concentration-dependent decrease in EGFR levels in pancreatic (PANC-1, MIAPaCa-2, and BxPC-3), colorectal (HCT116), prostate (PC3), and lung (H460) cancer cell lines; similar effects were observed in KATOIII gastric cancer cells but not in MKN45 gastric cancer cells (Fig. 3B and Fig. S5).