BBB leakage following cerebral ischemia in humans can be observed from 3 h to 7 days [20] and, on the endothelial level, is dependent on the destabilization of the tight junction complex and consecutively the para-endothelial influx of low-molecular-weight contrast agents up to large molecules such as albumin [21]. The gene discussed is ALB; the disease is Cerebral ischemia.