ESR1 and breast carcinoma: Recent analyses within the NLCS, the Nurses’ Health Study, and a Danish cohort study [11], [12], [13], [14] showed a positive association for endometrial, ovarian, and estrogen receptor-positive breast cancer, suggesting that disturbance of sex hormonal balances may be a mechanism of acrylamide carcinogenesis, which can also be suggested based on the rat carcinogenicity assays [7], [8].