TGFB1 and neoplasm: It has been well demonstrated that tumor-induced immune tolerance mostly arises from elevated immunosuppressive factors such as TGFβ [1], IL-10 [2], or PGE [3] and from tumor-induced modulatory cells with immunosuppressive properties such as those belonging to the subpopulation of T cells, dendritic cells (DCs), and the like [4, 5].