When we modeled the gene expression of SMNDC1, its TF regulator MYC is shown to have repression activity only during low levels of YY1. Although we detected co-occurring binding sites for both MYC and YY1, our expression model suggests that YY1 silences the repression activity of MYC. This is consistent with recent findings showing that YY1 negatively regulates MYC activity in certain tumour cells [37]. The gene discussed is TF; the disease is neoplasm.