We tested the expression of IGF-1, IGF-1R, IGF-2, IGF-2R, IGFBP-3, ERα and ERβ mRNA on 58 tumor tissue samples and 31 tumor-adjacent endometrial tissue samples from patients with EAC and 42 normal endometrial tissue samples, using RT-PCR. This evidence concerns the gene IGFBP3 and neoplasm.