The progressive impairment that we documented in the Tau.P301L mice, starting from defective learning and memory in adults to problems at later age with breathing and vocalization, swallowing, movement, and motor defects, Tau phosphorylation, and aggregation into tangles, all correspond with features known from human tauopathies and neurodegenerative diseases. The gene discussed is MAPT; the disease is neurodegenerative disease.