The GSK3 kinases appeal as candidates to modulate Tau phosphorylation for several reasons: (i) they are abundantly expressed in neurons, (ii) their levels and/or enzymatic activity is increased in AD brain [71, 72], and (iii) they can phosphorylate many of the S/T-P sites of protein Tau that are also phosphorylated in AD brain, that is, S199, T231, and S396 [73–75]. This evidence concerns the gene MAPT and Alzheimer disease.