Specifically, mutations in transactivation response DNA-binding protein (TARDBP) gene and in other genes associated with neuronal (NCIs) or glial (GCIs) cytoplasmic inclusions (i.e., fused in sarcoma/translocation in liposarcoma or FUS/TLS, C9ORF72, and progranulin or PGRN) have been identified in several familial or sporadic ALS and ALS/FTD cases [1, 52], and in subsets of FTD [52, 53]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.