In fact, immunohistochemical whole-brain analyses of autopsied ALS/FTD cases revealed TDP-43 deposits in multiple brain areas within and also beyond the pyramidal motor system, including the nigrostriatal system, neocortical and allocortical areas, and, to a variable extent, the cerebellum, although there were regional differences in the pathological burden between the various clinical phenotypes [6, 7]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.