PGF may also influence MM development by binding VEGFR-1 receptors on haematopoietic bone marrow precursors inducing mobilization and recruitment of inflammatory mediators that upregulate VEGF production around the tumour, and by binding VEGFR-1 expressing smooth muscle cells and pericytes, thereby affecting blood vessel maturation and stability [49]. Here, VEGFA is linked to Miyoshi myopathy.