We investigated the role of sEH in the pathogenesis of hepatic steatosis and found that as compared with an 8-week HF diet, a 16-week HF diet produced 2.6-fold increased sEH protein level in mouse liver (Fig. 5A) relative to the controls, with reinforced epoxide hydrolase activity of sEH (Fig. 5B). Here, EPHX2 is linked to hydrops fetalis.