The substrates of sEH include the epoxy products of omega-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) [15], which play a critical role in relieving hepatic steatosis by regulating nuclear factors involved in fatty acid de novo synthesis and utilization [16]. Here, EPHX2 is linked to Hepatic steatosis.