Rosenstock et al reported in a study [6] that eligible subjects had type 2 diabetes inadequately controlled by previous insulin therapy plus OHAs, an average duration of diabetes of >10 years, and baseline BMI of 36.7 kg/m2, and the daily insulin dose of BBT was 146 IU/day (1.4 IU/kg/day), among which the basal insulin doses was 54.9 IU/day (0.56 IU/kg/day). This evidence concerns the gene INS and type 2 diabetes mellitus.