First, univariate logistic regression was used for the six miRNAs along with sepsis stage (sepsis = 1, severe sepsis = 2, septic shock = 3), age, sex, SOFA scores, APACHE II scores, CRP and PCT levels, white blood cell counts (WBC), coronary heart diseases (CHD), diabetes, hypotension, and COPD. This evidence concerns the gene CRP and diabetes mellitus.