First, univariate logistic regression was used for the six miRNAs along with sepsis stage (sepsis = 1, severe sepsis = 2, septic shock = 3), age, sex, SOFA scores, APACHE II scores, CRP and PCT levels, white blood cell counts (WBC), coronary heart diseases (CHD), diabetes, hypotension, and COPD. The gene discussed is CRP; the disease is Sepsis.