TNF and neoplasm: Further quantification of the TUNEL-positive cells also revealed that TNF-α induces apoptosis of endothelial cells in most patients (69.6±9%) whereas for tumour cells, patients could be subdivided into three groups: patients with low apoptosis rate (10% to 17%, n = 2), patients with moderate apoptosis rate (57 to 66%, n = 3), and patients with high apoptosis rate (85% to 95%, n = 3), suggesting that sarcoma tumour cells are differentially sensitive to TNF-α-induced apoptosis (Fig. 1B).