The other putative amplicons in 17q21.33-q25.1 [24]–[26], 8p11.2 [27], [28] and 8q24.3 [19] have been previously reported as amplified in subsets of breast cancers but their association with tamoxifen resistance in ER+ breast cancer is a novel finding. The gene discussed is ESR1; the disease is breast carcinoma.