The overall alterations (deletion/methylation) of these genes in CIN and CACX were in the following order: CIN: SLIT2 (35%; 8/23) > ROBO1 (22%; 5/23) > ROBO2 (9%; 2/23) (Figure 2E, Table S2A,C); CACX: SLIT2 (59%; 65/110) > ROBO1 (58%; 64/110) > ROBO2 (43%; 47/110) (Table S2B,D). Here, ROBO1 is linked to cervical squamous intraepithelial neoplasia.