In addition deletion or methylation mediated deregulation of SLIT2 has already been reported in various malignancies including gliomas, neuroblastoma, Wilm’s tumor, leukemia and carcinomas of lung, breast, kidney, colon etc though, none reported the stage wise correlation pattern [15], [28]–[30], [33], [36]–[40]. Here, SLIT2 is linked to Nephroblastoma.