CDX1 and malignant colon neoplasm: We observed a similar trend of induction of pGL3/−1.2Cld-1-driven luciferase activity in HCT116 colon cancer, which was 2.5–3 fold upon overexpression of Cdx1 and GATA4 and ∼4-fold upon overexpression of Cdx2 (Figure 2C).