In this study, we investigate the effect of F. macrophylla extracts or isolated pure compounds on Aβ accumulation and found that they decrease extracellular accumulation of Aβ1-40 in the cultured mouse neuroblastoma cells N2a transfected with human Swedish mutant APP (swAPP-N2a cells) by inhibiting β-secretase or enhancing Aβ degradation. This evidence concerns the gene APP and neuroblastoma.