Previous PHPT reports have suggested that common mechanisms are responsible for the development of the metabolic syndrome and some studies examined these cardiometabolic abnormalities in detail [43], showing correlations between PTH and several variables (dyslipidemia, obesity, hypertension, and insulin resistance) observed in the metabolic syndrome, suggesting a role of PHT in development of abnormalities seen in this condition. This evidence concerns the gene PTH and obesity due to melanocortin 4 receptor deficiency.