Hypoglycemia can occur in any patient with diabetes when glucose consumption exceeds supply, but certain descriptors are more characteristic of those patients at greatest risk for severe hypoglycemia - younger age, longer duration of diabetes, lower HgbA1c, higher insulin dose, lower BMI, male, Caucasian, underinsurance or low socioeconomic status, and the presence of psychiatric disorders[37]. The gene discussed is INS; the disease is psychiatric disorder.